Ali Khan, PhD Candidate
Imaging Research Laboratories, Robarts Research Institute
"Improving brain registration and segmentation using anatomical guidance and intelligent atlas selection"
Neurodegenerative diseases afflict a significant portion of the world's aging population, with Alzheimer's disease (AD) alone affecting close to 500,000 Canadians. Non-invasive magnetic resonance imaging has shown potential to detect structural changes at an earlier stage than neuropsychological or cognitive evaluations, however, the high degree of anatomical variability among our brains has proven to be a challenge in developing general computational methods. Neuroanatomical registration and segmentation are fundamental components of many structural and functional analysis techniques, thus advances here can lead to the development of biomarkers for early disease progression. In this presentation I will present methods for improved accuracy and robustness using context-specific anatomical guidance in registration and intelligent atlas selection in multi-atlas segmentation, then demonstrate applications of these in shape analysis of the hippocampus in AD.
Monday, October 25, 2010 at 2:00 PM - at 3:00 PM
Robarts Research Institute, 2nd floor conference room